Clobetasol is a super potent (very strong) corticosteroid that's applied to the skin. It helps relieve skin inflammation and irritation from moderate-to-severe skin problems, like psoriasis. Clobetasol propionate is an ointment you can rub on your skin to treat eczema and psoriasis. It reduces swelling, redness, itching and rashes caused by these skin conditions. NHS medicines information on clobetasol – what it's used for, who can use it, how to apply it, side effects and dosage. Clobetasol propionate is used cosmetically for skin whitening, although this use is controversial. The US Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the US. Clobetasol is a prescription topical steroid used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. Learn about side effects, drug interactions, dosages, warnings, and more. Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more widely used in comparison. [2][3] Clobetasol propionate ranks among the most potent topical corticosteroids available for prescription use. It is classified as super potent on the topical steroid potency scale. Clobetasol is a highly potent corticosteroid that helps reduce inflammation in the body. It works by activating natural substances in the skin to reduce swelling, redness, and itching. Clobetasol is available in a cream, gel, ointment, lotion, solution, foam, or spray. Clobetasol topical is used to help relieve redness, itching, swelling, or other discomfort caused by certain skin conditions. Overview: Topical clobetasol is used to treat skin conditions that involve inflammation and itchiness, including psoriasis. Common side effects from topical clobetasol are skin reactions, such.